Early research has investigated the reason for the toxicity of beya amyloid peptides and whether it is linked to heredity.
In Alzheimer's disease beta amyloid plaques form in the brain alongside tau proteins which form tangles. Researchers at Whitehead Institute for Biomedical Research have created a GM yeast model and used it to screeb for genes which could alter the toxicity of amyloid beta. These genes idenified also affected the toxicity of beta amyloid peptides in worms and rat brain cells.
The model has also demonstrated that beta amyloid also disrupts endocytosis (absorbing and moving substances into the cell using vesicles) in yeast cells. Interestingly, the genes which regulate endocytosis in humans has already been identified as a risk factor for Alzheimer's.
Researchers are confident that these finding with the yeast model will be applicable to humans, however we are only at the early stages of research and will need to run experiments using human cells before this we can look at how to use the results to diagnose and treat the disease.
You may have noticed that over time I have made several posts on Alzheimer's disease. After attending Medlink and writing a medical report on the disease with a friend, I have become very interested in the news regarding treatment and diagnosis. I also decided to do my Year 12 biology coursework on Alzheimer's which gave me further opportunity to look at drug developments and the NICE recommendations.
This is the link for my medical report published on the web:
http://www.medlink-uk.org/Site/documents/Alzheimers2010/DayJ&BiggsK.pdf
http://www.nhs.uk/news/2011/10October/Pages/alzheimers-disease-genes-yeast.aspx
Thanks Kristy, for mentioning these latest findings. I too am interested in finding information regarding benefical options for slow the Early Memory Loss/Mild Cognitive Impairment before further deterioration occurs. I found that CerefolinNAC has the ingredients to help slow oxidative stress where neurons can get damaged and the formation of plaques and tangles are the result. This medication also brings the most bio-available L-Methylfolate beyond the blood brain barrier without any concern for MTHFR polymorphism disturbance. I work with this medication in addition to taking it. More information can be found at cerefolinnac.com
ReplyDeleteYou're right it is very interesting. I've had a look at the website- are there any published results from clinical trials? I would be interested in how they have performed in terms of their effectiveness. Thank you for bringing this to my attention
ReplyDeleteThank you for your patience - here are links to the few of the studies listed on literature:
ReplyDeletewww.ncbi.nlm.nih.gov/pubmed/20838622
and
www.ncbi.nlm.nih.gov/pubmed?term=M%20Morris%20circulating%20unmetabolized
I will see about getting other relevant information to you.